The Irish economy could be hit hard by the loss of the Transatlantic Trade and Investment Partnership (TTIP) and the possible loss of any EU-US free trade agreement.
The European Commission is considering whether to cancel a proposed deal with the US, which would see the Irish Government receiving up to €3 billion ($4.7 billion) a year in tax concessions.
It has also considered whether to withdraw from the deal.
The decision will be made by the EU Council, which will meet on Tuesday.
The US has said it will not seek to renegotiate the TTIP agreement.
But a spokesperson said the US was “deeply concerned” by the decision to cancel the agreement, which could be devastating for the Irish economy.
“We are considering our options, and we hope that the Government will honour its commitment to the deal,” the spokesperson said.
“However, if it does not, we will withdraw and pursue a constructive approach.”
The Irish government has been in talks with the United States for some time over the trade deal, which was announced in June and was expected to be signed by the end of the year.
The Irish Government has said the TTIF would help to protect jobs, boost investment and create jobs for the country.